Researchers conducted a study on post-menopausal women in a specific county to examine whether endometrial cancer was related to estrogen use. Cases of women with endometrial cancer were identified from this county, and a control group was selected matched to the case on age and length of residence in the county. Given the following observed frequencies, you need to test the claim that endometrial cancer was associated with estrogen use at the 0.05 significance level. What is the value of the appropriate test statistic?

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