Scopolamine is available in a transdermal patch for the treatment of motion sickness. You are involved in the design of a new patch for this drug and need to first determine the diffusion coefficient of the drug in the outer layer of the skin. To do this, you set up a diffusion cell using excised human skin (thickness=100m). The donor solution has a constant scopolamine concentration of 4.6mg/ml. The concentration in the receptor solution is maintained at a concentration very much smaller than 4.6 mg/ml. The skin section you use is circular with a radius of 0.5 cm. The amount of the drug that has passed through the skin versus time is given in the following Table. Using this data and the fact that scopolamine has a partition coefficient (skin/water) of 17.4, calculate the diffusion coefficient of scopolamine in the skin.

Total mass of scopolamine transported versus time

Cd = 4.6 mg/ml,

Cr << Cd, sink condition

h = 100 m

K = 17.4

S=r2= *(0.5cm)2

dM/dt = 5.5987*10-3mg/hr

This is the formula provided DM/DT=DS* KCd/h

PLease explain each step and what each abreviation means it will be highly appreciated********