Secobarbital (Seconal) is a short-acting barbiturate derivative that was previously used to treat insomnia, but has...

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Secobarbital (Seconal) is a short-acting barbiturate derivative that was previously used to treat insomnia, but has largely been replaced by drugs in the benzodiazepine family. It is the most frequently used drug in physician-assisted suicide in the United States. Provide reagents and the final product for the following synthesis of Secobarbital. For reagents in part A, show reagents and products for each step and for Part B provide a mechanism for this double aminolysis reaction (aminolysis can be found on page 95 of the bound notes). COCH3 COCH3 ? HN COCH3 A COCH3 NaOEt NH2 HOEt B Secobarbital Secobarbital (Seconal) is a short-acting barbiturate derivative that was previously used to treat insomnia, but has largely been replaced by drugs in the benzodiazepine family. It is the most frequently used drug in physician-assisted suicide in the United States. Provide reagents and the final product for the following synthesis of Secobarbital. For reagents in part A, show reagents and products for each step and for Part B provide a mechanism for this double aminolysis reaction (aminolysis can be found on page 95 of the bound notes). COCH3 COCH3 ? HN COCH3 A COCH3 NaOEt NH2 HOEt B Secobarbital

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Part A Synthesis of Secobarbital Step 1 Ethyl Acetoacetate to Diethyl Malonate Reagents NaOEt Sodium ... View the full answer