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Suppose the response rate of the standard treatment is about 35%. A new treatment is declared non-inferior to the standard treatment if its response rate
Suppose the response rate of the standard treatment is about 35%. A new treatment is declared non-inferior to the standard treatment if its response rate is no worse than the response rate of the standard treatment minus 0.05. To confirm non-inferiority, what is the sample size per treatment arm (assuming equal allocation) for the t-test (upper-sided) with = 0.05 and power 95%
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