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Suppose you were using the percentage difference method to determine the relationship between two variables of interest arranged in a bivariate table.Are there any instances

Suppose you were using the percentage difference method to determine the relationship between two variables of interest arranged in a bivariate table.Are there any instances where you might find a very large percentage difference yet fail to find statistically significant results after conducting a chi-square test?If so,what factorswould explain this?

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