The active toxin released during the Bhopal disaster is methylisocyanate (MIC), pictured below. It is used in the manufacturing of plastics, is a good electrophile, and has the ability to react with many biomolecules (proteins, etc.), especially those with nucleophilic functional groups (hydroxyls, amines). HC N=C=0 MC Q2 Homework - Unanswered What is the likely electrophile on MIC? Select an answer and submit. For keyboard navigation, use the up/down arrow ways to select as anwe. a CH3 b 2 d o Unanswered Q3 Homework Design an enzyme active site that contains a biomolecule-nucleophile that could attack MIC, and binds well to MIC. Begin by drawing MOC in the middle, and then build the active site around it. Your drawing should contain: MIC An Rgroup that is the nucleophile Any appropriate groups or other molecules needed for catalysis of this reaction Label the catalytics Rgroups in the bipding site Label the binding sites), -Draw sufficient groups that will do non covalent interactions with the entirety of MIC in the binding site 16-18 total, must not all be the same! All groups are appropriately positioned near the parts of Mic they interact with Next to every group provide 1-2 sentences of teasoning stating the group's function, and why it is appropriate -Do NOT draw a mechanism While drawing this, keep in mind what we have learned about engymes as catalysts and consider proximity, coming movement, and stabilizing the substrate "You may collaborate with others but I WILL NOT accept any identical answers. If you submit the same answer assume you will be awarded zero points. You will also be deducted points for exactly repeating any catalytic sites or binding sites or one or series Pullscreen Q4 Homework - Unanswered IF MIC were to be attacked by a nucleophile, it is likely that a negatively charged reactive intermediate would form. Using CER, describe two DIFFERENT ways that an enzyme could stabilize this intermediate, and why they are appropriate HE B i A. X. X 22- EE 66 I Pullscreen