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The ACTN3 gene encodes a protein which is expressed in muscle fibers that are responsible for generating rapid forceful contraction. There are three genoptypes:
The ACTN3 gene encodes a protein which is expressed in muscle fibers that are responsible for generating rapid forceful contraction. There are three genoptypes: RR, RX, and XX. You will be answering questions related to this gene based on data collected in the study:Yang, Nan & Macarthur, Daniel & Gulbin, Jason & G Hahn, Allan & H Beggs, Alan & Easteal, Simon & North, Kathryn. (2003). ACTN3 Genotype Is Associated with Human Athletic Performance. American journal of human genetics. 73. 627-31. 10.1086/377590. There are two groups in the study, a control group and a group of Elite Athletes. 1. We use Hardy-Weinberg to get expectations for genotype distribution. (a) Assuming that the alleles are equally likely, find the expected frequency of each type: RR: RX: XX: Multiplying by 436, the number of subjects in the control group, find the expected number of each type: RR: RX: XX: (b) Repeat part (a) assuming that the underlying proportion for allele R is .6. Expected frequency: RR: RX: XX: Expected number: RR: RX: XX:
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