The androgen receptor is the major receptor for androgens such as testosterone.  Mutations in the androgen receptor are the primary cause of Androgen Insensitivity Syndrome (AIS), which causes feminization of genetically XY individuals.  

1) How would a deleterious mutation (deleted, null mutation) in the androgen receptor gene affect the response of target tissues to testosterone?

 

   increase  /  decrease  /  normal

2) Would injections of testosterone hormone be a viable therapy for individuals with AIS?  Explain…