The data in the table below came from randomized controlled trials that tested the effectiveness of...

 

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The data in the table below came from randomized controlled trials that tested the effectiveness of Aspirin (versus placebo) in preventing death after a myocardial infarction (MI). The data from these studies were collected for the purpose of conducting a meta-analysis for a systematic review on the effectiveness of Aspirin. The purpose of a meta-analysis is to pool (combine) the data from multiple studies in order to provide an estimate of the treatment effect across the pooled studies. The labels in the table refer to the following: Study (study reference), dth plac (number of participants that died in the placebo group), tot plac (total number of participants in the placebo group), dth asp (number of participants that died in the aspirin group), and tot asp (total number of participants in the aspirin group). Use the data in this table to answer the questions below the table. < Study dth_plac tot plac dth_asp tot_asp 624 49 615 Elwood_etal_1974 67 Coronary_1976 Elwood Sweetman_1979 Breddin_etal_1979 77 44 757 126 850 102 832 38 309 32 317 Persantine 1980 52 406 85 810 Aspirin 1980 219 2257 346 2267 ISIS2_1988 1720 8600 1570 8587 A.>Conduct the appropriate statistical test to determine whether the proportion that died in the placebo group was greater than the proportion that died in the aspirin group for the ISIS2_1988 study. Assume =0.05. Show all calculations. < B. Conduct the appropriate statistical test to determine whether there is an association between treatment group (aspirin, placebo) and deaths (yes/no) in the Persantine_1980 study. Assume a=0.01. Show all calculations. The data in the table below came from randomized controlled trials that tested the effectiveness of Aspirin (versus placebo) in preventing death after a myocardial infarction (MI). The data from these studies were collected for the purpose of conducting a meta-analysis for a systematic review on the effectiveness of Aspirin. The purpose of a meta-analysis is to pool (combine) the data from multiple studies in order to provide an estimate of the treatment effect across the pooled studies. The labels in the table refer to the following: Study (study reference), dth plac (number of participants that died in the placebo group), tot plac (total number of participants in the placebo group), dth asp (number of participants that died in the aspirin group), and tot asp (total number of participants in the aspirin group). Use the data in this table to answer the questions below the table. < Study dth_plac tot plac dth_asp tot_asp 624 49 615 Elwood_etal_1974 67 Coronary_1976 Elwood Sweetman_1979 Breddin_etal_1979 77 44 757 126 850 102 832 38 309 32 317 Persantine 1980 52 406 85 810 Aspirin 1980 219 2257 346 2267 ISIS2_1988 1720 8600 1570 8587 A.>Conduct the appropriate statistical test to determine whether the proportion that died in the placebo group was greater than the proportion that died in the aspirin group for the ISIS2_1988 study. Assume =0.05. Show all calculations. < B. Conduct the appropriate statistical test to determine whether there is an association between treatment group (aspirin, placebo) and deaths (yes/no) in the Persantine_1980 study. Assume a=0.01. Show all calculations.