The distribution of blood types O : A : B : AB in the general population of South Africa are known to be in the ratio 33:46:15:6, respectively. A research team, investigating a 2 small isolated sub - population in the Eastern Cape, obtained the following frequencies of blood type from a random sample of people in the population:

(Table)

Blood Type: O, A, B, AB

Frequency: 22, 5, 17, 10

Test the hypothesis that the proportions in this isolated sub-population do not differ significantly from those in the general population, at a 1% level of significance