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The following data was obtained after carrying out a dissolution experiment using a constant surface method (temperature of experiment = 25C). time (min.) concn. (mol/L)
The following data was obtained after carrying out a dissolution experiment using a constant surface method (temperature of experiment = 25C). time (min.) concn. (mol/L) 5 0.006 10 0.012 15 0.018 20 0.024 30 0.037 40 0.050 The surface area of the solid was maintained constant at 2.45 cm2. The volume of the dissolution medium was 1000 cm3 and the equilibrium solubility of the drug in the dissolution medium was 1.4 moles/L (at 25 C). From the above data, calculate the dissolution rate constant? Explicitly state any assumptions that you make.
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