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The following PK values are known for the antiarrhythmic agent, procainamide: F=0.83, fu =0.84,CLMetabolism=2.8ml/min/kg for slow acetylators and 5.9ml/min/kg for fast acetylators. CLRenal=2.7CLCR,,V=1.9L/kg,TI=48g/ml Q1: Design
The following PK values are known for the antiarrhythmic agent, procainamide: F=0.83, fu =0.84,CLMetabolism=2.8ml/min/kg for slow acetylators and 5.9ml/min/kg for fast acetylators. CLRenal=2.7CLCR,,V=1.9L/kg,TI=48g/ml Q1: Design an iv. Infusion for Mr. QG, a 94kg,510 tall, 57 year old patients who is a fast acetylator, to be treated for arrhythmia. Mr. QG has SCR of 1.4mg/dl. Q2: Would you recommend a loading dose for this patient? If yes, how much and if no, why not? Q3: If the patient had been a female patient, age 42 , weigh 69kg,44 tall, and a slow acetylator, SCR of 1.9mg/ what would be your answers to Q1 and Q2 above
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