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The phosphorylation of glucose to glucose 6-phosphate is the initial step in the catabolism of glucose. The direct phosphorylation of glucose by P1 is described

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The phosphorylation of glucose to glucose 6-phosphate is the initial step in the catabolism of glucose. The direct phosphorylation of glucose by P1 is described by the equation Glucose+Piglucose6-phosphate+H2OG=13.8kJ/mol The phosphorylation of glucose in the cell is coupled to the hydrolysis of ATP. Part of the energy from ATP hydrolysis is used to phosphorylate glucose. Glucose+Piglucose6-phosphate+H2OATP+H2OADP+PiG0=+13.8kJ/molG0=30.5kJmol Sum: Glucose + ATP glucose 6-phosphate + ADP Calculate Keq at 37.0C for the overall reaction. The maximum solubility of glucose is less than 1M. The normal physiological concentration of glucose 6-phosphate (G6P) is 250M. If the concentration of ATP is 3.38mM and the concentration of ADP is 1.32mM, what concentration of glucose is needed to achieve a 250M intracellular concentration of G6P ? [Glucose] Determine whether the coupling of ATP hydrolysis to the phosphorylation of glucose provides a feasible route, at least in principle, for the phosphorylation of glucose in the cell. Is this coupling process feasible for glucose phosphorylation in the cell

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