The step-by-step explanation is missing for Question #2.

In a cohort study with no loss to follow-up, the disease status was misclassified as follows:

Study Population without Misclassification

IllHealthy

Exposed 5003,000

Unexposed 250 3,250

Study Population with Misclassification

Ill Healthy

Exposed650 2,850

Unexposed200 3,300

a. What is the most appropriate relative measure of association to use in this study?

The most appropriate relative measure of association is the Risk Ratio for unbiased.

b. Comparing the study population with and without misclassification using this measure of association, is there evidence of information bias?

c. If there is evidence of information bias, is it differential or non-differential? Explain why by comparing the errors in misclassification of disease between the exposed and unexposed.

d. If there is information bias, is it towards or away from the null? Why?