The tutor sent this see below The following are the phases of bone cancer in children:

1. The cancer has not progressed to any neighboring tissues and is just present in the bone. This is the first stage.

2. The cancer has progressed to neighboring tissues but has not yet reached any distant organs in stage II.

3. At this stage, the cancer has spread to other organs in the body.

Explanation:

The disease has not spread to any of the tissues that are close by and is just present in the bone at this stage.

• At this stage, the cancer has not spread to any of the tissues that are close by; it is confined to the bone only. There is no set size or shape for the tumor, and it can affect any section of the bone. There is a possibility that there are cancer cells in the bone marrow; however, they have not yet migrated to the blood.

The cancer has progressed to neighboring tissues but has not yet reached any distant organs at stage II.

• The cancer has moved from the bone to the tissues that are close by, but it has not yet migrated to the organs that are further away. The size of the tumor is arbitrary. There is a possibility that there are cancer cells in the bone marrow; however, they have not yet migrated to the blood.

The cancer has spread to other organs in the body at this stage.

• The cancer has moved on from the bone and into other organs in the body. The size of the tumor is arbitrary. There is a possibility that there are cancer cells in the bone marrow; however, they have not yet migrated to the blood.

• The fact that it is frequently very challenging to treat is the most significant disadvantage of juvenile bone cancer. The malignancy has the potential to spread rapidly and is frequently aggressive. Because of this, treatment may become more challenging, and the patient may have more severe adverse effects.

Key references:

1. Glass, N. E., Riccardi, J., Farber, N. I., Bonne, S. L., & Livingston, D. H. (2020). Disproportionally low funding for trauma research by the National Institutes of Health: A call for a National Institute of Trauma.Journal of Trauma and Acute Care Surgery,88(1), 25-32.
2. Hartley, I. R., Gafni, R. I., Roszko, K. L., Brown, S. M., de Castro, L. F., Saikali, A., ... & Florenzano, P. (2022). Determination of FGF23 Levels for the Diagnosis of FGF23Mediated Hypophosphatemia.Journal of Bone and Mineral Research.

Malik, A. A., Baig, M., Butt, N. S., Imran, M., Alzahrani, S. H., & Gazzaz, Z. J. (2022). Bibliometric Analysis of Global Research Productivity on Vitamin D and Bone Metabolism (2001-2020): Learn from the Past to Plan Future.Nutrients,14(3), 542.

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