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the visual sensory cells in the retina of the eye continuously release the neurotransmitter glutamate in the dark. It is assumed that the neurotransmitter release

the visual sensory cells in the retina of the eye continuously release the neurotransmitter glutamate in the dark. It is assumed that the neurotransmitter release is temporally and locally constant everywhere on the presynaptic membrane and that the glutamate concentration on the presynaptic membrane surface is 1mM.(see description of synapse structure in figure 1) a) suppose that glutamate binds to receptors on the postsynaptic membrane and is transported into the postsynaptic cell so that the glutamate concentration remains constant at 0.3mM on the surface of the postsynaptic membrane. What is the glutamate flux (molecule/m^2s) through the synaptic gap when the distance between the pre- and postsynaptic membrane is 50nm? The diffusion coefficient at body temperature is 37C D=7.6*10^-6 cm^2s^-1 and you can assume the synaptic gap to be water. b) Now the temperature of the head is 20C during surgery. The viscosity of water at 37C is 0.688 mPas and at 20 it is 1.002 mPas. How much glutamate flux decreases with this decrease in head temperature. Assume glutamate concentrations remain unchanged.

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