Sufficient component cause models and potential outcomes models You are interested in whether any lifetime exposure to a certain drug (E=1) increases risk of Alexander Disease (a rare, progressive neurological disorder) compared with having no drug exposure (E=0). There are only 3 sufficient causes for Alexander Disease to which all people are susceptible, shown below. U1 U2 U1 U3 U2 U3 E-1 E=0 U4 Sufficient Cause 1 Sufficient Cause 2 Sufficient Cause 3 You conduct a cohort study, enroll people at risk of developing Alexander Disease, and assess their lifetime drug exposure at the beginning of the study. Participants are categorized as either exposed (E=1) or unexposed (E=0) at the beginning of the study, and their exposure status does not change during study follow-up. You follow all study participants for 5 years, and no study participants are lost to follow up. The table below shows the time from the beginning of the study until each component cause is filled (in years) for all study participants. The study participants fall into 3 groups based on when they fill each component cause as shown in the Table. Group A Component cause completion time (years) U1 U2 U3 U4 4 7 3 9 4 3 2 1 3 1 6 7 B ? Question 3 3 pts True or False: If the sufficient component cause model is correct, then there are no necessary causes of Alexander Disease. O True False Question 4 3 pts If we were able to remove all drug exposure from the entire population, we would prevent 33% of all cases of disease. Select the one best answer. True False O Not enough information Question 5 3 pts What is the potential outcome type for the individuals in Group A (recall that 'potential outcome' types are defined as occurring during the study's specified follow-up period)? Select the one best answer. O Type 1: Doomed Type 2: Exposure causal Type 3: Exposure preventative Type 4: Immune Question 6 3 pts What is the potential outcome type for the individuals in Group B (recall that 'potential outcome' types are defined as occurring during the study's specified follow-up period)? Select the one best answer. O Type 1: Doomed O Type 2: Exposure causal Type 3: Exposure preventative O Type 4: Immune Question 7 3 pts What is the potential outcome type for the individuals in Group C (recall that potential outcome' types are defined as occurring during the study's specified follow-up period)? Select the one best answer. O Type 1: Doomed O Type 2: Exposure causal O Type 3: Exposure preventative Type 4: Immune