TRYP-Assignment #2

Question 1

Hepatitis C (HCV): if results from the polymerase chain reaction (PCR)

examination are inconclusive, what does this mean? Should further

investigations be undertaken and, if so, will there be a risk of chronicity?

Question 2

In a patient with hepatitis C and autoimmune hepatitis, can

corticosteroids be prescribed for the autoimmune hepatitis?

Question 3

We were told that the more vascular a structure is, the more antigen

(HLA/blood groups) matching is needed for transplantation, e.g. cornea

transplant needs no matching. However, the liver is a very vascular

organ; I don't know why liver transplantation needs blood group

matching only but renal transplantation needs much more HLA

matching.

Question 4

About steatohepatitis: please give me more information about the

occurrence of cirrhosis in such patients (non-alcoholic) and is there

any role and indication for lipotropic agents and hypocholesterolaemic

drugs?

Question 5

I am working on non-alcoholic fatty liver disease (NAFLD) but I did not

find anything regarding it. Can you tell me about its relationship with

lipids?

Question 6

Is NASH a valid term or not and what manifestation has it?

Question 7

Is terlipressin better in controlling variceal bleeding than somatostatin?

Question 8

Why is there a hyperdynamic circulation in cirrhosis?

Question 9

Why is there an increased level of immunoglobulin G (IgG) in patients

with cirrhosis?

Question 10

Cirrhosis of liver is reversible according to your book. What is the

progress and when will we be able to counteract the 'tissue inhibitors

of metalloproteinases' (TIMPs) and thus save the lives of our

patients?