TSH is released into the bloodstream and therefore is delivered to all cells of the body.

1. What determines which cells of the body will respond to a specific hormone such as TSH?  Which organ is this located?

 2. Cells of what gland have receptors for TRH?

 3. What type of physiological change(s) would stimulate the entire hypothalamus-pituitary-thyroid axis?

 4. How would the removal of the thyroid gland affect levels of TRH, TSH, and TH?  Draw out the H-P-T axis to illustrate changes in hormone levels.

5. What symptoms would result from removal of the thyroid gland (before hormone replacement)?

Draw normal H-P-thyroid pathway	Draw the pathway with missing thyroid