Use the effectiveness of Excedrin on phonophobia in the pooled sample (Table 14) at hour 6. That is, for the sake of simplicity, assume that the effect of Excedrin on phonophobia symptoms represents the full effect of it on migraine attacks.

Next, calculate how many migraine attacks could be prevented if every person with migraine is prescribed Excedrin.

Using your answer to the previous question, how many hours of work loss could be prevented if all the migraine patients have access to Excedrin?

What is the dollar value of prevented work loss?

Compare the dollar value of prevented work loss to the total cost of Excedrin. Does providing every migraine patient Excedrin pass the cost-benefit test?

Assuming Excedrin passes the CB test, does your net benefit represent the upper or lower bound of Net Benefit of potential Excedrin Use?

SOURCE: https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/20-802S002_Excedrin_statr.pdf