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Want to stop smoking? Nicotine patches may help, and so may taking a drug that fights depression. A report in a recent issue of the New England Journal of Medicine describes a study of what works best. Here is part of the summary:

Use of nicotine replacement therapies and the antidepressant bupropion helps people stop smoking. We conducted a double-blind, placebo-controlled comparison of sustained-release bupropion (244 subjects), a nicotine patch (244 subjects), bupropion and a nicotine patch (245 subjects), and placebo (160 subjects) for smoking cessation.

Results. The abstinence rates at 12 months were 15.6% in the placebo group, as compared with 16.4%in the nicotine patch group, 30.3% in the bupropion group, and 35.5% in thegroup given bupropion and the nicotine patch.