Question
Using ubuntu program (on Windows) nano command line, please answer the questions about shell scripts 1) Merging two files for a flexible lookup program OMIM
Using ubuntu program (on Windows) nano command line, please answer the questions about shell scripts
1) Merging two files for a flexible lookup program
OMIM (Online Mendelian Inheritance in Man; https://www.omim.org/) is a widely used online database that contains information about genetic disorders, and the genes and genomic regions that are associated with these disorders. genemap2.txt file (https://www2.unb.ca/~rmalenf1/BIOL3933/genemap2.txt) and morbidmap.txt
(https://www2.unb.ca/~rmalenf1/BIOL3933/morbidmap.txt) contain the most important parts of the OMIM database. Respectively, they contain the locations of genes and genomic locations associated with genetic disorders.
You would like to write a simple script to check if a mutation at a particular nucleotide is located somewhere in the range of a gene, and you would also like to check if the mutation is located in a region that is associated with a genetic disorder.
-Download their URL and use command-line arguments to specify the location of interest, so that it is not hardcoded.
For example, to check if position 4,671,231 on chromosome 3 is in the range of any genes or associated with any genetic conditions, I would run my script as follows, and get the following result:
Erene]% ./Malenfant-Rene-Part2.sh chr3 4671231 This SNP is in the range of these genes: ARHI2 ITPR1, SCA15, SCA16, SCA29 These genes are associated with the following conditions: ARHI2 Age-related hearing impairment 2 (2) ITPR1, SCA15, SCA16, SCA29Gillespie syndrome, 206700 (3) ITPR1, SCA15, SCA16, SCA29 Spinocerebellar ataxia 15, 606658 (3) ITPR1, SCA15, SCA16, SCA29 Spinocerebellar ataxia 29, congenital nonprogressive, 117360 (3) Erene]% ./Malenfant-Rene-Part2.sh chr3 4671231 This SNP is in the range of these genes: ARHI2 ITPR1, SCA15, SCA16, SCA29 These genes are associated with the following conditions: ARHI2 Age-related hearing impairment 2 (2) ITPR1, SCA15, SCA16, SCA29Gillespie syndrome, 206700 (3) ITPR1, SCA15, SCA16, SCA29 Spinocerebellar ataxia 15, 606658 (3) ITPR1, SCA15, SCA16, SCA29 Spinocerebellar ataxia 29, congenital nonprogressive, 117360 (3)Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started