Question
Warfarin (or Coumadin) is used to prevent blood clots in humans, but is a poison used to kill rats at high does (results in
Warfarin (or Coumadin) is used to prevent blood clots in humans, but is a poison used to kill rats at high does (results in internal bleeding). Warfarin (W) binds to human plasma albumin (A) with the reaction shown below. The apparent data at 25C for this reaction are AG=-30.8 KJ/mol, AH=-13.1 kJ/mol and AC,-0, which can be used to determine the equilibrium constant. W+AWA (a) What is the entropy change for this reaction at 25C? (b) What is the fraction of unbound albumin over a temperature range of 0 to 50C, assuming that concentrations of warfarin and human albumin are 0.0001 M.
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Separation Process Principles Chemical And Biochemical Principles
Authors: By J. D. Seader, Ernest J. Henley, D. Keith Roper
3rd Edition
0470481838, 978-0470481837
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