Wayne Eckerson used this rather simple concept: "BI consists of two diametrically opposed activities: top-down, metrics-driven reporting, and dashboarding where you know in advance what things you want to monitor, and bottom-up, ad hoc analysis to answer unanticipated questions."

1 Is growth hormone deficiency in childhood commonly associated with panhypopituitarism?

2 I would like to ask why, when treating hypopituitarism, an adrenal crisis occurs if thyroid replacement is given before steroid replacement therapy? And what is the underlying mechanism? Thank you!

3 Why, in Sheehan's syndrome, is there an anterior pituitary involvement more than a posterior one?

4 Is the cyclic presence of Montgomery tubercles, where they reduce and later increase, in a nulliparous woman's breast normal? And, if so, what is the cause?

5 Does methyltestosterone, if given in a daily dose of 2.5 mg per day, cause liver cell injury or hypothalamic gonadal suppression? Can this drug be prescribed for other cases with hypothalamic hypogonadism, usually being given by intramuscular injection or implant?

6 Does IM testosterone increase levels of serum thyroid-stimulating hormone (TSH)?

7 For some time now I have been confused regarding tests for acromegaly 1. Which is best - screening or diagnosing test in these patients? 2. Your book says the 'glucose tolerance test [GTT] is diagnostic'. Does this mean GTT with growth hormone (GH) evaluation or that a patient who is clinically an acromegalic with a positive GTT (diabetic) can be labelled as acromegalic? Incidentally, a lot of people around me are similarly confused and others have been following the latter saying that 'Kumar and Clark say so'. Please clarify.

8 Does acromegaly cause depression?

9 1. Breathlessness can be a feature of acromegaly. What are the characteristics of this breathlessness? 2. If a patient presents with headaches due to acromegaly, what are the likely characteristics of these headaches?

10 Why does hypothyroidism cause a transudative pleural effusion?