We evaluated the efficacy of a hepatitis care coordination intervention to improve linkage to hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccination and clinical evaluation of hepatitis C virus (HCV) infection among methadone maintenance patients. Methods. We conducted a randomized controlled trial of 489 participants from methadone maintenance treatment programs in San Francisco, California, and New York City from February 2008 through June 2011. We randomized participants to a control arm (n = 245) and an intervention arm (n = 244), which included on-site screening, motivational-enhanced education and counseling, on-site vaccination, and case management services. Of the 150 participants in the intervention group who needed the combined HAV--- HBV vaccine, 115 received the vaccine within 30 days of the vaccine being recommended. Of the 150 participants in the control group who needed the combined HAV-HBV vaccine,18 received the vaccine within 30 days of the vaccine being recommended.

- Do the estimated risk difference, relative risk and odds ratio agree in terms of the direction of association?