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What are the implications of somatic mutations in normal tissue aging and age-related diseases, including cancer, cardiovascular disease, and neurodegeneration, and how do clonal expansion

  1. What are the implications of somatic mutations in normal tissue aging and age-related diseases, including cancer, cardiovascular disease, and neurodegeneration, and how do clonal expansion of somatic mutations and genomic mosaicism contribute to tissue dysfunction and aging phenotypes ?

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