What is the difference between anatomy and physiology? How are they related? Anatomy refers to structure and physiology refers to function. Structure determines function. Give one specific example of how the structure and function of a cell are related. Give one specific example of how the structure and function of a tissue are related. What and where are the structures in the skin that serve as effectors in the negative feedback regulation of body temperature? How do they respond when one is in a very hot environment?