When there is a problem with carbohydrate metabolism, as in starvation or diabetes mellitus, two acetyl-CoA molecules combine to produce acetoacetate and two free CoA-SH. b-ketoacids, like acetoacetate, are relatively strong acids. The presence of large amounts of b-ketoacids in the blood can lower blood pH from 7.4 to 7.3 or even 7.2, a condition known as acidosis, which leads to coma and death. Which of the following molecules are b- ketoacids? 1. H3C 3. HO O 1 only O 3 & 4 O 1, 2, 3, & 4 1, 3, & 4 C- 2 only-CH-C-CH-CH-C OH 2. OH H3C-CH-CH-C- OH 4. H3C OH - OH