Which of the following is not correct in relative to ketone bodies? $*$

Ketone bodies are a water soluble equivalent of Acetyl$-$CoA units.

Some tissues, such as cardiac muscle, preferentially use ketone bodies.

The brain can use ketone bodies under conditions of long term starvation.

Because of their acidity, high concentrations of ketone bodies can be detrimental.

The muscle is the major source of ketone bodies.