Which of the folowing statements oxplains how O2 terding to harrogiobin intiates coopenatye binding in the proten a) The binding of CO2 and H+to the hnmogiobh subunts results in the oxidation of the Fo from its +2 to +3 state and initiates cooperatwe binding. b) The binding of the thilai O2 to hemogiobin reduces the radus of the rom alowing a to put inte the plane of the heme, this movement renuta in a conformational change in the protein and iniluates cooperative binding. c) The binding of 2,3 hisphosphoglyperate to the fuly deaxygenated form of hemogiohin intales cooperative binding in than protein. d) The binaing of the intial O2 molecule to hemoglobin axidizes the heme iron from its +2 to +3 state, reduoing the rabius of lhar iron alowing it to puil into the plane of the heme, this mevement results in a contormational change in the protein and intates cooperative binding. As irteversble intibtor; D) usually covalently binds to the actlve sae of the enzyme. b) usually binds to the active sito of the enfyme in a noncovalent manner. F onty binds to enzymes which folow the lock and key model of ES formaton. 5) decreases the Kim but has no effect on the Vmax of the enzyme. Euthew to Which statement below regarding positive modulators of alosteric enzymes is true, a) Positive modulaters have no effect on the Km of the ariostenc entyme. b) Only the substrate(s) for the erzyme can serve as postive modulators. c) Positive modulators ilwayt increase the Keat of the alosseric erizyme. d) Postive modulators always bind to the cazalytic subunt of the enzyme. 1) At of the clataments above are false