Which one of the following statements is true of enzyme catalysts?A$)$ They bind to substrates, but are never covalently attached to substrate or product.B$)$ They increase the equilibrium constant for a reaction, thus favoring product formation.C$)$ They increase the stability of the product of a desired reaction by allowing ionizations, resonance, and isomerizations not normally available to substrates.D$)$ They lower the activation energy for the conversion of substrate to product.E$)$ To be effective they must be present at the same concentration as their substrate