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You are working to design a skin patch that delivers a drug to the body. Examples of patches on the market today include the Nicoderm
You are working to design a skin patch that delivers a drug to the body. Examples of patches on the market today include the Nicoderm patch for helping individuals to quit smoking and patches that contain hormones, including estrogen and testosterone. The skin patch is thin and flat and has a surface area of
It is placed on the arm with one side up against the skin and the other side exposed to the air. Your intention is to design a patch that delivers a pain medication that might be used after surgery or traumatic injury. To minimize the risk of addiction, the amount of drug delivered decreases as a function of time. You conduct a number of tests, as described below, to help design and characterize the patch. In all tests below, ignore drug and water losses from the edges sides of the patch.
For each test please do the following:
a Draw the system, boundary, and surroundings.
b State all reasonable assumptions for the system.
c Write and simplify the accounting equation for the system.
d Write the appropriate mass conservation equation for the system.
e Answer the question asked of each test.
Test A As noted above, the amount of drug delivered decreases as a function of time. Your research has shown that the rate the drug leaves the patch, is described by the following formula:
where is the time. Assume that the drug is delivered from the patch to the skin and that no drug is lost to the air. Assuming that the patch is loaded with of drug, how long does it take before the drug is exhausted from the patch?
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