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You have been hired by a consulting firm to assist in the development of a drug delivery polymer device to deliver leuprolide, a polypeptide

 

You have been hired by a consulting firm to assist in the development of a drug delivery polymer device to deliver leuprolide, a polypeptide drug used as a prostate cancer treatment. You are given two unknown polymers. You did some degradation experiments and obtained the following data. Time (hr) 0 250 500 750 1000 Polymer 1 MW g/mol 2305 2298 2312 2301 2308 Thickness mm 1.5 1.3 1.0 0.54 0.06 Polymer 2 MW g/mol 45000 23780 9960 4320 1420 Thickness mm 1.19 1.17 1.18 1.17 1.19 a) What kind of erosion did Polymer 1 undergo? Propose the name of a polymer that would exhibit this kind of erosion. (a) Draw a general chemical structure of this polymer and indicate the bonds sensitive to hydrolysis under physiologic conditions; show the chemical structure of the immediately resulting products that are generated from the hydrolysis. [5 pt] b) What kind of erosion did Polymer 2 undergo? Propose the name of a polymer that would exhibit this kind of erosion. (Make any assumptions necessary) [5 pt]

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