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Your colleagues in upstream production have made a major progress in increasing the volumetric productivity of a fermenter through a higher cell density. As a
Your colleagues in upstream production have made a major progress in increasing the volumetric productivity of a fermenter through a higher cell density. As a consequence, the viscosity of the feed stream applied to your capture chromatography has increased from to mPa s If the initial column had a bed length of m and a diameter of m and was operated at delta P of bar with a linear flow rate of m h what will be the dimensions of the new column if the volumetric flux and resolution should be maintained? How could you increase the volumetric flux without affecting pressure, linear flow rate and resolution?
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