Your Company is testing the efficacy/toxicity of the new investigational pharmaceutical compound ABX. They administered ABX to a healthy volunteer (male, 31 year old, 80 kg) as a single intravenous injection of 5 mg/kg. The following plasma concentrations were collected:

Time (hours)	Conc. (g/mL)
0.1		1.142
0.5		1.0627
1		0.9712
8		0.2755
16		0.0653
24		0.0155
48		0.0002

Calculate:

1. Volume of distribution
2. Elimination rate constant
3. Elimination half-life
4. Area under the curve
5. Clearance
6. The concentration at t=10 hours
7. The amount in the body at t=10 hours
8. The fraction of the dose left in the body at t=24 hours
9. How many half-lives it takes to eliminate 90% of the dose?

j) What is the duration of action for compound ABX in this subject given that the minimum effective concentration is 0.25 g/mL?

Predict:

1. The plasma concentration at t=0 following a dose of 10 mg/kg
2. The plasma concentration at t=14 hours for the 10mg/kg dose
3. The fraction of the dose left in the body at t=24 hours
4. The duration of the effect for the 10mg/kg dose

Preliminary studies in monkeys indicated the onset of severe side effects when the plasma concentration exceeds 10 g/mL. What is the maximum dose that can be administered in this subject?