???????? Should there be limits placed on methadone treatment requiring people to be weaned from the drug after a certain period of time, or should they be permitted to take methadone as long as they feel they need it? A variety of therapeutic drugs are used to treat drug addiction, including disulfiram for alcoholism, nicotine replacement for smoking dependence, antidepressants for cocaine dependence, and the most controversial of all, the opioid methadone to treat dependence on the opioid heroin. It may seem ironic, indeed paradoxical, to use drugs to treat problems with drugs.