Compare the required solvent volume, stage number, and purity obtained when penicillin F is extracted from water

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Compare the required solvent volume, stage number, and purity obtained when penicillin F is extracted from water preferentially to penicillin K into amyl acetate at pH 3.1 relative to the values at pH 3.75. The respective pKa values for penicillin F and K are 3.51 and 2.77, and the respective KoD values are 131 and 215.

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Separation Process Principles Chemical And Biochemical Principles

ISBN: 9780470481837

3rd Edition

Authors: By J. D. Seader, Ernest J. Henley, D. Keith Roper

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