The article Assessment of Dermopharmacokinetic Approach in the Bioequivalence Determination of Topical Tretinoin Gel Products (L. Pershing,
Question:
The article “Assessment of Dermopharmacokinetic Approach in the Bioequivalence Determination of Topical Tretinoin Gel Products” (L. Pershing, J. Nelson, et al., J Am Acad Dermatol 2003:740–751) reports that the amount of a certain antifungal ointment that is absorbed into the skin can be modeled with a lognormal distribution. Assume that the amount (in ng/cm2) of active ingredient in the skin two hours after application is lognormally distributed with μ = 2.2 and σ = 2.1.
a. Find the mean amount absorbed.
b. Find the median amount absorbed.
c. Find the probability that the amount absorbed is more than 100 ng/cm2.
d. Find the probability that the amount absorbed is less than 50 ng/cm2.
e. Find the 80th percentile of the amount absorbed.
f. Find the standard deviation of the amount absorbed.
Step by Step Answer: