Bioreactor production of antibodies. Benchtop bioreactors are used to produce antibodies for anti-cancer drugs. Engineers calibrate bioreactors

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Bioreactor production of antibodies. Benchtop bioreactors are used to produce antibodies for anti-cancer drugs. Engineers calibrate bioreactors in order to maximize production. The African Journal of Biotechnology (December 2011) published a study designed to achieve a high percentage of antibody production from a bioreactor. The variable of interest was the natural logarithm of the number of viable cells produced in a bioreactor run. Data were collected for a sample of four bioreactor runs every 6 hours for 20 consecutive time periods. These data (simulated from information provided in the article) are listed in the accompanying table. Engineers have specified the following for the bioreactor runs: target mean = 6.3, LSL = 5.9, and USL = 6.5. Run a complete capability analysis on the data. How would you categorize the performance of the process? Time Period Hour Run1 Run2 Run3 Run4 1 0 5.83 5.90 5.91 5.93 2 6 5.98 5.94 5.97 5.84 3 12 5.99 5.98 5.99 5.98 4 18 6.09 6.04 5.93 6.02 5 24 6.20 6.30 6.30 6.20 6 30 6.04 6.08 6.23 6.15 7 36 6.19 6.13 6.13 6.29 8 42 6.37 6.27 6.27 6.27 9 48 6.56 6.46 6.36 6.26 10 54 6.36 6.36 6.16 6.16 11 60 6.36 6.37 6.37 6.27 12 66 6.27 6.27 6.27 6.17 13 72 6.26 6.26 6.26 6.16 14 78 6.29 6.46 6.16 6.26 15 84 6.26 6.16 6.25 6.15 16 90 6.35 6.45 6.25 6.53 17 96 6.16 6.16 6.55 6.56 18 102 6.24 6.23 6.24 6.24 19 108 6.15 6.16 6.15 6.15 20 114 6.30 6.52 6.13 6.48

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Statistics For Business And Economics

ISBN: 9781292413396

14th Global Edition

Authors: James McClave, P. Benson, Terry Sincich

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