Antiviral Therapy. In the article “Improved Outcome for Children With Disseminated Adenoviral Infection Following Allogeneic Stem Cell Transplantation” (British Journal of Haematology, Vol. 130, Issue 4, p. 595), B. Kampmann et al. examined children who received stem cell transplants and subsequently became infected with a variety of ailments. A new antiviral therapy was administered to 11 patients. Their absolute lymphocyte counts (ABS lymphs) (×109/L) at onset and resolution were as shown in the following table.

Onset Resolution Onset Resolution 0.08 0.59 0.31 0.38 0.02 0.37 0.23 0.39 0.03 0.07 0.09 0.02 0.64 0.81 0.10 0.38 0.03 0.76 0.04 0.60 0.15 0.44

a. Obtain normal probability plots and boxplots of the onset data, the resolution data, and the paired differences of those data.

b. Based on your results from part (a), is applying a one-mean t-procedure to the onset data reasonable?

c. Based on your results from part (a), is applying a one-mean t-procedure to the resolution data reasonable?

d. Based on your results from part (a), is applying a paired t-procedure to the data reasonable?

e. What do your answers from parts (b)–

(d) imply about the conditions for using a paired t-procedure?

Working with Large Data Sets