The biggest difference between an enzyme-catalyzed reaction and an uncatalyzed reaction is that (A) The free energy

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The biggest difference between an enzyme-catalyzed reaction and an uncatalyzed reaction is that
(A) The free energy between the reactants and the products does not change
(B) The free energy difference between the reactants and the products does not change
(C) The catalyzed reaction would not occur without the enzyme
(D) A different amount of energy is required to reach the transition state of the reaction

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