The glycolysis pathway shown in figure has a number of intermediates that contain phosphate groups. Why can
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The glycolysis pathway shown in figure has a number of intermediates that contain phosphate groups. Why can 3-phosphoglyceryl phosphate and phosphoenolpyruvate transfer a phosphate group to ADP while glucose 6-phosphatecannot?
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CH2он но a-Glucose но- он OH O Glucose is phosphorylated by reaction with ATP to yield glucose 6 phosphate. ATP ADP н- HO- сн-OPО, но a-Glucose HO 6-phosphate H- HO- но- Он он -HO- Glucose 6-phosphate is isomerized to fructose 6 phosphate by ring opening tollowed by a keto-enol tautomerization. CH2OPO,2- ҫнрон -O3POCH2 CH2он C=0 a-Fructose но но 6-phosphate Н HO- Он ОН O Fructose 6 phosphate is phosphorylated by reaction with ATP to yield fructose 1,6-bisphosphate. ATP CH2OPO,?- ADP CH2OPO,- 2-OPOCH2 он C=0 B-Fructose 1,6-bisphosphate но но -н CH2OPO, Н HO- Он ОН O Fructose 1,6-bisphosphate undergoes ring opening and is cleaved by a retro-aldol reaction into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP). DHAP then isomerizes to glyceraldehyde CH2OPO,- 3-phosphate. но о Гсн-он -0,Росн-снсн 2-O3POCH,ČCH,OH C=0 HO- H- Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate | Cн-ОPО CH2OPO,
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