Question: The reaction catalyzed by malate dehydrogenase, has a G°' = 4.6 kJ mol-1. (a) Would this reaction occur spontaneously in a cell? (b) How does

The reaction catalyzed by malate dehydrogenase,

has a ˆ†G°' = 4.6 kJ ˆ™ mol-1.
(a) Would this reaction occur spontaneously in a cell?
(b) How does the citrate synthase reaction promote the malate dehydrogenase reaction in the cell? What is the overall change in free energy for the two reactions?

Malate + NAD+ oxaloacetate + NADH + H+

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