Triosephosphate isomerase catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a general-base and a general-acid catalyst, respectively. Propose a mechanism for the reaction.

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oPOCH2CCH2OH dihydroxyacetone phosphate triosephosphate isomerase PH CH OIH glyceraldehyde-3-phosphate