When an ?-hydroxy amide is treated with Br2 in aqueous NaOH under Hofmann rearrangement conditions, loss of

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When an ?-hydroxy amide is treated with Br2 in aqueous NaOH under Hofmann rearrangement conditions, loss of CO2 occurs and a chain-shortened aldehyde is formed. Propose a mechanism.

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Organic Chemistry

ISBN: 9780495112587

7 Edition

Authors: John McMurry

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Question Posted: Mar 08, 2011 04:38 AM

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When an ?-hydroxy amide is treated with Br2 in aqueous NaOH under Hofmann rearrangement conditions, loss of

Question:

Он NH2 н NH3 Br2 NaOH, H20 CO2 +

Step by Step Answer:

NH H 32533 H NH Br NaOH HO NH3 NH3 Hofm...View the full answer

Organic Chemistry

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