B cells suppress the expression of all but one heavy chain allele and one light chain allele,

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B cells suppress the expression of all but one heavy chain allele and one light chain allele, a process known as allelic exclusion, by inhibiting the further somatic recombination of heavy and light chain genes after a productive recombination has occurred. Describe the aberrant properties of immunoglobulins produced by a B cell in which allelic exclusion is defective.
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Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

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