Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates that accumulate in

Question:

Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates that accumulate in the presence of those compounds.

Fantastic news! We've Found the answer you've been seeking!

Step by Step Answer:

Related Book For book-img-for-question

Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

See More Books

Question Posted: Apr 30, 2016 02:53 PM

See More Questions

6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases. (a) Which intermediate or intermediates in purine nucleotide biosynthesis would you expect to accumulate in...
Certain microorganisms with a modified citric acid cycle decarboxylate a -ketoglutarate to produce succinate semi-aldehyde: (a) Succinate semialdehyde is then converted to succinate, which is further...
Consider three engines that each use 1650 J of heat from a hot reservoir (temperature = 550 K). These three engines reject heat to a cold reservoir (temperature = 330 K). Engine I rejects 1120 J of...
Simplify the following expressions according to the commutative law: a. b. A B + A C + B A c. (L M N)(A B)(C D E)(M N L) d. F (K + R) + S V + W + V S + W + (R + K) F A.B + B.A + C.D.E + C.DE + E.T.D
Fiona is a professional bass violinist with the St. Paul Symphony Orchestra. In February of the current year, she purchases at auction for $200,000 an eighteenth-century bass violin built by the...
The following expenditures were incurred in connection with a large new ma chine acquired by a metals manufacturing company. Identify those which should be included in the cost of the asset, (a)...
Convince yourself that (11.9) is correct. (11.9)
Refer to the clustering problem involving the file FBS described in Problem 1. The NCAA has a preference for conferences consisting of similar schools with respect to their endowment, enrollment, and...
How many of the following variances are unfavorable? Item Budget Actual Sales price $350 $380 Sales revenue $15,000 $12,500 Cost of goods sold $10,000 $9,000 Selling and administrative expenses...
From "The Journey of Man Movie: Genetic Odyssey, please answer all questions. 5. Where does Dr. Wells suggest that the ancestors of Europeans came from? Why did they move? 6. If Africa is the cradle...
In the synthesis of FAD, riboflavin is phosphorylated by a kinase to form FMN (Fig. 18-10). The FMN then reacts with ATP. How many "high-energy" bonds are broken in this process?
Rats are given cytidine that is 14C-labeled at both its base and ribose components. Their DNA is then extracted and degraded with nucleases. Describe the labeling pattern of the recovered...
a. Is the interest received from government obligations taxable? Explain. b. What impact does the fact that some bond interest is tax exempt have on interest rates? c. Is an investor always better...
Question 2: Response to John Ripley?
Prepare a summary of the effects of the "fat tax" on the demand and supply diagram. Ensure you talk about the dead weight loss. PRICE D Tax Revenue S P1 P2 TAX P3 Dead Weight Loss QUANTITY QeAT QeBT...
Trade causes production in Home to move from point A to point B. What does this mean happened to the relative price of Qc? QF Home QF1 A QF2 Qc Qc2 Qc2
Write as an ordered pair the coordinates of the point whose y-coordinate is 3 and whose x-coordinate is -7. X Viewing Saved Work Revert to Last Response
1. A cereal manufacturer tests their equipment weekly to be assured that the proper amount of cereal is in each box of cereal. The company wants to see if the amount differs from the stated amount on...
Which statement is not correct? a. The essence of data consolidation as a data integration pattern is to capture the data from multiple, heterogeneous source systems and integrate it into a single...
In each of the following independent cases, document the system using whatever technique(s) your instructor specifies. a. Dreambox Creations (www.dreamboxcreations.com/) in Diamond Bar, California,...
In what forms does potential energy enter a microbial ecosystem? Which energy classes of microorganisms can exploit each?
Explain why both obligately anaerobic and obligately aerobic bacteria can often be isolated from the same soil sample.
The surface of a rock in a flowing stream will often contain a biofilm. What advantages could be conferred on bacteria growing in a biofilm compared with growth within the flowing stream?
Ray Company provided the following excerpts from its Production Department's flexible budget performance report. Required: Complete the Production Department's Flexible Budget Performance Report....
Problem 1 5 - 5 ( Algo ) Lessee; operating lease; advance payment; leasehold improvement [ L 0 1 5 - 4 ] On January 1 , 2 0 2 4 , Winn Heat Transfer leased office space under a three - year operating...
Zafra and Stephanie formed an equal profit- sharing O&S Partnership during the current year, with Zafra contributing $100,000 in cash and Stephanie contributing land (basis of $60,000, fair market...

Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates that accumulate in

Question:

Step by Step Answer:

PRPP and FGAR accumulate because they are substrates of Reactions 2 and 5 in the IMP biosynthetic pathway Fig 231 XMP also accumulates because the GMP synthetase reaction is blocked Fig 233 Although glutamine is a substrate ...View the full answer

Fundamentals of biochemistry Life at the Molecular Level

Students also viewed these Medical Sciences questions