Hemoglobin (abbreviated Hb) is a protein that is responsible for the Transport of oxygen in the blood of mammals. Each hemoglobin molecule contains four iron atoms that serve as the binding sites for O2 molecules. The oxygen binding is pH dependent. The relevant equilibrium reaction is

Use Le Chatelier€™s principle to answer the following,
a. What form of hemoglobin, HbH44+ or Hb(O2)4, is favored in the lungs? What form is favored in the cells?
b. When a person hyperventilates, the concentration of CO2 in the blood decreases. How does this affect the oxygen-binding equilibrium? How does breathing into a paper bag help to counteract this effect?

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HbH," (aq) + 402ig) = Hb(O2\4(aq) + 4H*(aq)