Question: In hemoglobin Rainier, Tyr 145 is replaced by Cys, which forms a disulfide bond with another Cys residue in the same subunit. This prevents the

In hemoglobin Rainier, Tyr 145β is replaced by Cys, which forms a disulfide bond with another Cys residue in the same subunit. This prevents the formation of ion pairs that normally stabilize the T state. How does hemoglobin Rainier differ from normal hemoglobin with respect to
(a) Oxygen affinity,
(b) The Bohr effect, and
(c) The Hill constant?

Step by Step Solution

★★★★★

3.48 Rating (158 Votes )

There are 3 Steps involved in it

1 Expert Approved Answer

Step: 1 Unlock

a Because the mutation destabilizes the T conformation of hemoglobin ... View full answer

Question Has Been Solved by an Expert!

Get step-by-step solutions from verified subject matter experts

Step: 2 Unlock

Step: 3 Unlock

Document Format (1 attachment)

930-M-S-B-C (1139).docx

120 KBs Word File

Students Have Also Explored These Related Biochemistry Questions!

In the variant hemoglobin C, glutamate at position 6 of the chain has been replaced with lysine. (a) Would you expect this mutant hemoglobin to polymerize as hemoglobin S does? (b) Red blood cells...

Hemoglobin (C2952H4664N812O832S8Fe4) is the oxygen carrier in blood. (a) Calculate its molar mass. (b) An average adult has about 5.0 L of blood. Every milliliter of blood has approximately 5.0 109...

Hemoglobin (Hb) is a blood protein that is responsible for transporting oxygen. It can exist in the protonated form as HbH+. The binding of oxygen can be represented by the simplifi ed equation HbH+...

In one particular hemoglobin variant the Tyr 145 B is replaced by a Cys which causes formation of an unusual disulfide in this subunit. This prevents the formation of ion pairs that stabilize the T...

Hemoglobin Rainier (HbR) is a mutant in which Tyr 145 of the -globin is replaced by Cys. This Cys forms an intramolecular disulfide with Cys93 in the oxy state but cannot form the intramolecular...

##################>### ############################################# ####################### ### ####### ####################################################################### ###!###"#######$###...

Five people were asked to join the expedition investigating the snow leopard, which lives in very high mountain altitudes. Each of the people is heterozygous for one of the following mutant...

A protein has a molecular mass of 400 kDa when measured by gel filtration. When subjected to gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), the protein gives three bands with...

Please help with all parts and there is table below for reference. Thank you so much! Table 1. pka values for amino acid side chains and N- and C-terminal groups Amino Acid pk, value Tyr 10.07 Cys...

Helix Propensities for all 20 amino acids Residue Pa Ala 1.42 Arg 0.98 Asn 0.67 Asp 1.01 Cys 0.70 GIn 1.11 Glu 1.51 Gly 0.57 His 1.00 Ile 1.08 Leu 1.21 Lys 1.16 Met 1.45 Phe 1.13 Pro 0.57 Ser 0.77...

Find the equivalent annual worth for the cash flows shown, using an interest rate of 12% per year. Monetary units are$1000. Year Cash Flow, $ 20 20 20 20 60 60 60 60 60

Simtek currently pays a $2.50 dividend (D0) per share. Next years dividend is expected to be $3 per share. After next year, dividends are expected to increase at a 9 percent annual rate for three...

How does the inflation affect the economy of a country?

The breaking strength of yarn supplied by two manufacturers is being investigated. We know from experience with the manufacturers processes that 1 5 and 2 4 psi. A random sample of 20 test...

Explain why water forms nearly spherical droplets on the surface of a freshly waxed car. Why doesn't water bead on a clean windshield?

Describe what happens when a dialysis bag containing pure water is suspended in a beaker of seawater. What would happen if the dialysis membrane were permeable to water but not solutes?

(a) Assuming the cell membrane is permeable to water but not to ions, describe what will happen to the cell in terms of osmosis. (b) If the membrane were permeable to ions, in which direction would...

Please answer all the questions what is asked in number 1-6 ma'am/sir. Thank you! 1. Do social robots walk or roll? According to the United 2. Beach erosional hotspots. Beaches that exhibit high ero-...

example of ids 1 0 5 module five

Adapted AICPA Task-Based Simulation Youu are involved with the audit of Jelco Company for year 1 and have been asked to consider the confirmation reply results indicated below. For each confirmation...