64. The article Increases in Steroid Binding Globulins Induced by Tamoxifen in Patients with Carcinoma of the

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64. The article “Increases in Steroid Binding Globulins Induced by Tamoxifen in Patients with Carcinoma of the Breast”

(J. Endocrinology, 1978: 219–226) reports data on the effects of the drug tamoxifen on change in the level of cortisolbinding globulin (CBG) of patients during treatment. With age  x and CBG  y, summary values are n  26, xi 

1613, (xi  x

)2  3756.96, yi  281.9, (yi  y

)2 

465.34, and xi yi  16,731.

a. Compute a 90% CI for the true correlation coefficient .

b. Test H0:   .5 versus Ha:   .5 at level .05.

c. In a regression analysis of y on x, what proportion of variation in change of cortisol-binding globulin level could be explained by variation in patient age within the sample?

d. If you decide to perform a regression analysis with age as the dependent variable, what proportion of variation in age is explainable by variation in CBG?

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